U.S. Full Prescribing Information, including Boxed WARNING Medication Guide
U.S. Healthcare Professionals Indication

Indication

CAMZYOS is a prescription medicine
used to treat adults with symptomatic
obstructive hypertrophic cardiomyopathy
(HCM). CAMZYOS may improve your
symptoms and your ability to be active.

It is not known if CAMZYOS is safe and effective in children.

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CAMZYOS Works Differently

Rx CAMZYOS® (mavacamten) works differently video

See how CAMZYOS works to target
the source of obstructive HCM deep
within the heart muscle.

To understand how CAMZYOS works, it’s helpful to know how certain proteins help contribute to the pumping action of your heart:

Legend

Connected myosin protein

Connected
myosin

Resting myosin protein

Resting
myosin

Actin protein

Actin

Rx CAMZYOS® (mavacamten) binding to myosin protein

CAMZYOS
binding to
myosin

Scroll to see how CAMZYOS works.

Click each box to see how CAMZYOS works.

Normal heart

Normal heart

Two proteins in the heart muscle, called myosin and actin, contribute to your heart pumping by connecting (making the heart contract) and releasing (allowing the heart to relax).

Heart with obstructive HCM

Heart with obstructive hypertrophic cardiomyopathy (oHCM)

In obstructive HCM, myosin and actin form too many connections with each other, causing the heart to contract too much, which can make it difficult for it to relax.

How CAMZYOS works in a
heart with obstructive HCM

Heart with obstructive hypertrophic cardiomyopathy (oHCM) with Rx CAMZYOS® (mavacamten)

CAMZYOS binds to myosin so that it “lets go” of actin, reducing the excessive connections between them. This action allows your heart muscle to relax more.

Why is it important to know how CAMZYOS works?

In people with symptomatic obstructive HCM, reducing the connections between myosin and actin
may decrease the obstruction and improve heart function (how the heart relaxes and fills with blood).

To learn more about CAMZYOS, please see U.S. Full Prescribing Information, including Boxed WARNING and Medication Guide.

Learn How CAMZYOS May Help

3500-US-2200350 08/22