U.S. Full Prescribing Information, including Boxed WARNING Medication Guide
U.S. Healthcare Professionals Indication

Indication

CAMZYOS is a prescription medicine
used to treat adults with symptomatic
obstructive hypertrophic cardiomyopathy
(HCM). CAMZYOS may improve your
symptoms and your ability to be active.

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See the difference CAMZYOS is making for people
living with symptomatic obstructive HCM

Hover to learn more about real CAMZYOS patients. Click to watch patient stories.

Tap to learn more about real CAMZYOS patients. Tap to watch patient stories.

All patients and their family members were compensated for their time. Individual results may vary.

Stephanie, a Rx CAMZYOS® (mavacamten) patient, and her husband, Ed

Stephanie

Before being on CAMZYOS, climbing a flight of stairs caused a lot of symptoms for me, and now I can climb that flight of stairs again.
—Stephanie

Symptoms made it difficult for me to attend sporting events, but now I’m getting back to watching them
—Kim

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How has CAMZYOS made a difference for you?

Share Your Story
Dani, a Rx CAMZYOS® (mavacamten) patient, and her daughter, Kassidy

Dani

Since taking CAMZYOS, my symptoms have been improving and things have changed for the better.
—Dani

Greg, a Rx CAMZYOS® (mavacamten) patient

Greg

With my symptoms improving, I’m getting lost in books again.
—Greg

Connie, a Rx CAMZYOS® (mavacamten) patient, sewing

Connie

Thanks to CAMZYOS improving my symptoms, I'm back to doing what I love most—quilting.
—Connie

Dustin, a Rx CAMZYOS® (mavacamten) patient, and his wife, Emily, looking at pictures on a wall

Dustin

More things are
possible now.
—Dustin

I thought I had to settle for a less active lifestyle. CAMZYOS helped improve my ability to be active and now I realize I don't have to settle.
—John

READY TO TALK TO YOUR
DOCTOR ABOUT CAMZYOS?

Find Resources

HCM=hypertrophic cardiomyopathy.

Stephanie, a Rx CAMZYOS® (mavacamten) patient

Read Stephanie's Story

Stephanie was a marathon runner who had to give up running and gradually lowered her level of activity over the years. She was recently diagnosed with symptomatic obstructive HCM after her symptoms of shortness of breath and heart palpitations worsened. On the day she was diagnosed, her cardiologist mentioned surgical options for her HCM. As her own advocate, she met with another cardiologist who prescribed CAMZYOS.

Kim, a Rx CAMZYOS® (mavacamten) patient

Kim

Being able to hike in nature again has transformed my life.
—Kim

Rebecca, a Rx CAMZYOS® (mavacamten) patient, riding her bike

Rebecca

I never thought I’d feel this way again, and I’m so grateful to CAMZYOS for helping to improve my symptoms.
—Rebecca

Dani, a Rx CAMZYOS® (mavacamten) patient

Read Dani's Story

Dani was diagnosed with obstructive HCM in her 50s. It started with symptoms like shortness of breath or fatigue while doing simple things like shopping or walking. When she was diagnosed, Dani tried an oral medication, but her obstruction didn’t improve and she eventually needed a myectomy, a type of open heart surgery. Despite this, and having tried a few other treatment options, her symptoms did not improve. Then, her doctor prescribed CAMZYOS.

My symptoms made me give up so much I felt like I was disconnected from the people I love. Now I'm able to reconnect.
—Connie

LEARN HOW CAMZYOS MAY HELP YOU

See Study Results
Dustin, a Rx CAMZYOS® (mavacamten) patient, and his wife, Emily

Read Dustin's Story

At the age of 10, Dustin watched his father pass from complications with HCM. Diagnosed with HCM in college, he “didn’t want to believe it” and denied his condition for years. Learn why Dustin finally faced his symptomatic obstructive HCM and how CAMZYOS made a difference in his life.

John, a Rx CAMZYOS® (mavacamten) patient with his dog

John

With my symptoms
improved, I can keep
up with my dog.
—John

Mike, a Rx CAMZYOS® (mavacamten) patient, smiling with his wife, Amy on their bikes

Mike

CAMZYOS has really made a difference in my life. My symptoms improved to the point where I am not so afraid anymore of being able to participate in many of the activities I love doing.
—Mike

Stephanie, a Rx CAMZYOS® (mavacamten) patient, and her husband, Ed

Stephanie

Before being on CAMZYOS, climbing a flight of stairs caused a lot of symptoms for me, and now I can climb that flight of stairs again.
—Stephanie

Stephanie, a Rx CAMZYOS® (mavacamten) patient

Read Stephanie's Story

Stephanie was a marathon runner who had to give up running and gradually lowered her level of activity over the years. She was recently diagnosed with symptomatic obstructive HCM after her symptoms of shortness of breath and heart palpitations worsened. On the day she was diagnosed, her cardiologist mentioned surgical options for her HCM. As her own advocate, she met with another cardiologist who prescribed CAMZYOS.

Symptoms made it difficult for me to attend sporting events, but now I’m getting back to watching them
—Kim

Share to Inspire logo

How has CAMZYOS made a difference for you?

Share Your Story
Kim, a Rx CAMZYOS® (mavacamten) patient

Kim

Being able to hike in nature again has transformed my life.
—Kim

Rebecca, a Rx CAMZYOS® (mavacamten) patient, riding her bike

Rebecca

I never thought I’d feel this way again, and I’m so grateful to CAMZYOS for helping to improve my symptoms.
—Rebecca

Dani, a Rx CAMZYOS® (mavacamten) patient

Dani

Since taking CAMZYOS, my symptoms have been improving and things have changed for the better.
—Dani

Dani, a Rx CAMZYOS® (mavacamten) patient

Read Dani's Story

Dani was diagnosed with obstructive HCM in her 50s. It started with symptoms like shortness of breath or fatigue while doing simple things like shopping or walking. When she was diagnosed, Dani tried an oral medication, but her obstruction didn’t improve and she eventually needed a myectomy, a type of open heart surgery. Despite this, and having tried a few other treatment options, her symptoms did not improve. Then, her doctor prescribed CAMZYOS.

My symptoms made me give up so much I felt like I was disconnected from the people I love. Now I'm able to reconnect.
—Connie

LEARN HOW CAMZYOS
MAY HELP YOU

See Study Results
Greg, a Rx CAMZYOS® (mavacamten) patient

Greg

With my symptoms improving, I’m getting lost in books again.
—Greg

Connie, a Rx CAMZYOS® (mavacamten) patient, sewing

Connie

Thanks to CAMZYOS improving my symptoms, I'm back to doing what I love most—quilting.
—Connie

Dustin, a Rx CAMZYOS® (mavacamten) patient, and his wife, Emily, looking at pictures on a wall

Dustin

More things are
possible now.
—Dustin

Dustin, a Rx CAMZYOS® (mavacamten) patient, and his wife, Emily

Read Dustin's Story

At the age of 10, Dustin watched his father pass from complications with HCM. Diagnosed with HCM in college, he “didn’t want to believe it” and denied his condition for years. Learn why Dustin finally faced his symptomatic obstructive HCM and how CAMZYOS made a difference in his life.

I thought I had to settle for a less active lifestyle. CAMZYOS helped improve my ability to be active and now I realize I don't have to settle.
—John

READY TO TALK TO YOUR
DOCTOR ABOUT CAMZYOS?

Find Resources
John, a Rx CAMZYOS® (mavacamten) patient with his dog

John

With my symptoms
improved, I can keep
up with my dog.
—John

Mike, a Rx CAMZYOS® (mavacamten) patient, smiling with his wife, Amy on their bikes

Mike

CAMZYOS has really made a difference in my life. My symptoms improved to the point where I am not so afraid anymore of being able to participate in many of the activities I love doing.
—Mike

HCM=hypertrophic cardiomyopathy.
HOW CAMZYOS
MAY HELP

In a clinical study, people
taking CAMZYOS experienced
changes in their symptoms and
ability to be active.

See Study Results
TALKING WITH
YOUR DOCTOR

If you have obstructive HCM and
are experiencing symptoms, talk
to your doctor to learn more
about CAMZYOS.

Get Discussion Tips

Learn about resources and
support that may be available
to you if you are considering
CAMZYOS or on therapy.

Get Support

Important Facts About CAMZYOS® (mavacamten)

This is a summary of important information that you need to know about CAMZYOS. Your healthcare provider can work with you to help answer any questions you may have about this medication. Keep this information in a safe place so you can refer to it before and during your treatment.

  • Look out for the following icons as you read:

  • Talk to your healthcare provider

  • Call a healthcare provider right away

  • Helpful information to remember

What is CAMZYOS?

CAMZYOS is a prescription medicine used to treat:

adults with symptomatic obstructive hypertrophic cardiomyopathy (obstructive HCM). CAMZYOS may improve your symptoms and your ability to be active.

WARNING: RISK OF HEART FAILURE

  • CAMZYOS may cause serious side effects, including heart failure.
  • Heart failure, a condition where the heart cannot pump with enough force, is a serious condition that can lead to death.

You must have echocardiograms before you take your first dose and during your treatment with CAMZYOS to help your healthcare provider understand how your heart is responding to CAMZYOS. Echocardiograms (echos) are imaging tests, a type of ultrasound study, which take pictures of your heart and show how well your heart is working.

People who develop a serious infection or irregular heartbeat have a greater risk of heart failure during treatment with CAMZYOS.

  • Get medical help right away if you experience new or worsening symptoms, including:
    • shortness of breath
    • chest pain
    • fatigue
    • racing heart (palpitations)
    • leg swelling
    • rapid weight gain

The risk of heart failure is also increased when CAMZYOS is taken with certain other medications. Tell your healthcare provider about the medicines you take, both prescribed and obtained over-the-counter, before and during treatment with CAMZYOS.

Because of the serious risk of heart failure, CAMZYOS is only available through a restricted program called the CAMZYOS Risk Evaluation and Mitigation Strategy (REMS) Program. This means:

  • You and your healthcare provider must both be enrolled in the CAMZYOS REMS program in order to have it prescribed. Talk to your healthcare provider about how to enroll and for more information about the program.
  • Your healthcare provider and pharmacist will make sure you understand how to take CAMZYOS safely, which includes returning for echos when advised by your healthcare provider.
  • You can only get CAMZYOS from a certified pharmacy that is part of the CAMZYOS REMS program. Talk to your healthcare provider about finding a certified pharmacy. You will not be able to get CAMZYOS from a local pharmacy.
  • If you have questions about the CAMZYOS REMS program, ask your healthcare provider, visit www.CAMZYOSREMS.com or call 1-833-628-7367.

What should I discuss with my healthcare provider before starting CAMZYOS?

  • Talk to your healthcare provider about all of your medical conditions, including if:
    • You are pregnant or plan to become pregnant – CAMZYOS may harm your unborn baby

      Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with CAMZYOS. You may also report your pregnancy by calling Bristol Myers Squibb at
      1-800-721-5072 or www.bms.com.

      If you are a female and able to become pregnant, your healthcare provider will do a pregnancy test before you start receiving CAMZYOS. You should use an effective method of birth control (contraception) during treatment and for at least 4 months after your last dose of CAMZYOS.

      • CAMZYOS may reduce how well hormonal birth control works. Talk to your healthcare provider about the use of effective forms of birth control during treatment with CAMZYOS.
    • You are breastfeeding or plan to breastfeed

      It is not known if CAMZYOS passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment with CAMZYOS.

What medicines should I discuss with my healthcare provider?

  • Tell your healthcare provider about all of the medicines you take before and during treatment with CAMZYOS, including:
    • prescription medicines
    • over-the-counter medicines
    • vitamins
    • herbal supplements
      • prescription medicines
      • over-the-counter medicines
      • vitamins
      • herbal supplements

Taking CAMZYOS with certain medicines or grapefruit juice may cause heart failure.

  • Especially tell your healthcare provider if you:
    • take over-the-counter medicines, including medications like omeprazole (for example, Prilosec®), esomeprazole (for example, Nexium®), or cimetidine (for example, Tagamet®)
    • take other medicines to treat your obstructive HCM disease
    • develop an infection
      • take over-the-counter medicines, including medications like omeprazole (for example, Prilosec®), esomeprazole (for example, Nexium®), or cimetidine (for example, Tagamet®)
      • take other medicines to treat your obstructive
        HCM disease
      • develop an infection
  • Do not stop or change the dose of a medicine or start a new medicine without telling your healthcare provider.

What are the serious side effects of CAMZYOS?

A serious side effect is a side effect that can sometimes become life-threatening and can lead to death.

  • CAMZYOS may cause serious side effects, including heart failure (a condition where the heart cannot pump with enough force).
    • Get medical help right away if you experience new or worsening symptoms, including:
      • shortness of breath
      • chest pain
      • fatigue
      • racing heart (palpitations)
      • leg swelling
      • rapid weight gain

What are the most common side effects?

The most common side effects of CAMZYOS include dizziness and fainting (syncope).

  • Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of CAMZYOS.

  • Talk to your healthcare provider for more information about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects to Bristol Myers Squibb at 1-800-721-5072.

How should I take CAMZYOS?

  • Before starting treatment with CAMZYOS, your healthcare provider will do an echocardiogram (echo) to assess your obstructive HCM. Your heart must be regularly monitored with echos while on treatment to help your healthcare provider understand how your heart is responding to CAMZYOS.
    • Talk to your healthcare provider for more information about echos and your echo schedule.

CAMZYOS comes in immediate release capsules, containing 2.5, 5, 10, or 15 mg of mavacamten. Each capsule is marked with the word MAVA and the number of milligrams (mg) it contains.

Inactive ingredients: croscarmellose sodium, hypromellose, magnesium stearate (non-bovine), mannitol, and silicon dioxide.

Capsule: contains black iron oxide, gelatin, red iron oxide, titanium dioxide, and yellow iron oxide.

Take CAMZYOS exactly as your healthcare provider tells you.

  • Once a day, by mouth
  • Swallow the capsule whole
  • Do not break, open, bite, or chew the capsule
  • Do not change your dose of CAMZYOS without talking to your healthcare provider first

Talk to your healthcare provider about the right dose for you.

What if I miss a dose?

  • Take it as soon as possible and take your next dose at your regularly scheduled time the next day.
  • Do not take two doses on the same day to make up for a missed dose.

Your healthcare provider may change your dose, temporarily stop, or permanently stop your treatment with CAMZYOS if you have certain side effects.

What if I take too much CAMZYOS?

  • Call your healthcare provider or go to the nearest hospital emergency room right away.

How should I store CAMZYOS?

Store CAMZYOS capsules between 68°F-77°F (20°C-25°C). Keep CAMZYOS and all medicines out of the reach of children.

  • For more information, please see the U.S. Full Prescribing Information, including Boxed WARNING, and Medication Guide for CAMZYOS. Talk to your healthcare provider for more information about this medication.

3500-US-2300080 02/23